1.
BMJ Case Rep
; 14(11)2021 Nov 11.
Article
in English
| MEDLINE | ID: covidwho-1515267
ABSTRACT
Idiosyncratic drug-induced agranulocytosis is a rare life-threatening adverse reaction characterised by an absolute neutrophil count <500 cells/µL of blood. Nitrofurantoin has been associated with haematological adverse events, but few agranulocytosis cases worldwide have been reported. We present a case of a 68-year-old woman who presented with fever and agranulocytosis following treatment with nitrofurantoin. Extensive workup for agranulocytosis, including a bone marrow aspirate, was unremarkable. Treatment with nitrofurantoin was discontinued, which led to a complete recovery of the complete blood count. This case stresses the importance of monitoring treatments, given that widely used drugs are not free from severe adverse reactions.
Subject(s)
Neutropenia , Nitrofurantoin , Aged , Blood Cell Count , Female , Humans , Leukocyte Count , Neutrophils , Nitrofurantoin/adverse effects
2.
Rheumatology (Oxford)
; 59(8): 2171-2173, 2020 08 01.
Article
in English
| MEDLINE | ID: covidwho-610246